Determination of Prothrombin Time, Activated Partial Thromboplastin Time, Fibrinogen Level and Platelet Count in Patients with Type II Diabetes Mellitus

Abstract

Background: The majority of patients with type II diabetes mellitus develop atherothrombosis and venous thromboembolism (VTE).One of the most complications of diabetes mellitus that includes coagulation imbalance. This study aimed to measure prothrombin time, activated partial thromboplastin time, fibrinogen levels and platelet count in patients with type II diabetes mellitus. Materials and Methods: This is a case control study, 120 participants were enrolled; 60 patients were known cases with type II Diabetes Mellitus; their mean age is 49 years admitted to the Kosti Teaching Hospital, and the other 60 normal individual were selected as controls. Coagulation profile included; prothrombin time (PT), Activated Partial Thromboplastin Time (APTT) and Fibrinogen Level were measured by fully automated Coagulometer Analyzer Thrombolyser XRC, while the Platelets count was counted by full automated hematological Analyzer (Sysmex KXN-21).Data were analyzed by using statistical package for social sciences (SPSS) version 20.The differences were considered statistically significant when P value less than 0.05 Results: The glucose as expected and fibrinogen levels were statistically significantly higher in patients with type II Diabetes Mellitus in comparison with the normal control group with (P value (0.00 and 0.00) respectively. While PT and APTT were statistically significantly shorter in patients with type II Diabetes Mellitus in comparison with the normal control group with P value (0.00 and 0,00) respectively. Platelet count showed no statistically significance difference in patients with type II Diabetes Mellitus in comparison with the normal control group with P value (0.485). Conclusion: This study concluded that PT and APTT were significantly shorter, while the Plasma fibrinogen level was elevated in Sudanese diabetes mellitus patients. Key words: Prothrombin Time; Activated Partial Thromboplastin Time, Fibrinogen; Platelet count; Diabetes Mellitus; Sudan.