مجلة المختبرات الطبية - 2016 - 2- 2

Permanent URI for this collectionhttps://repository.neelain.edu.sd/handle/123456789/3123

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Author: search.filters.author.Hiba A. AwoodaHas files: Yes

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    Prothrombin Time, Activated partial Thromboplastin Time and Platelets Count in Pregnant Females and Postpartum Period with Deep Venous Thrombosis
    (Al Neelain University-Faculty of Medical Laboratory Sciences, 2016-02) Huda I. Babiker; Hiba A. Awooda; Sana E. Abdalla
    Background: Venous thromboembolism is one of the major causes of maternal morbidity and mortality, the aims of this work was to determine the levels of (Prothrombin time (PT), activated partial thromboplastin time (APTT) and platelets count (PLts)) in pregnant and postpartum females affected with deep venous thrombosis (DVT). Methods: This is a hospital based case control study conducted at Omdurman maternity hospital and Khartoum teaching hospital in Khartoum state, Sudan.The study involved 30 females divided in to two groups: Study group included fifty females of child bearing age (15-45) years presented with signs of DVT either during pregnancy or postpartum period were investigated for PT, APTT and Plts count and fifty, and control group of either pregnant and postpartum femals presented without signs of DVT, the study and control females completed questionnaire of personal data and clinical history such as age, usage of contraceptive pills, family history of DVT and number of pregnancies. Automated coagulometer method used to measure PT and APTT. While PLTs counted using automated haematological analyzer Sysmex K 21. Results: PT was prolonged in vast majority of case group (90%), while it was normal in 10% of study population. APTT was prolonged in 62% of patients, mostly higher in third trimester with percentage of 69.4%. Platelets count found normal in vast majority of patients in all 3 trimesters. Prolonged prothrombin times showed highly significant association between and cases and control groups (P = 0.000), no significant association between prolonged PT and APTT in the third trimester among the study population. Conclusion: Normal platelets level where found in both control and study group, while PT is significally prolonged among cases (P =0.00). APTT is also prolonged in study group; but no statistically significant association found when compared with control group.
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    Hemoglobin Patterns in Patients with Sickle Cell Hemoglobinopathies
    (Al Neelain University-Faculty of Medical Laboratory Sciences, 2016-02) Eman A. Ajjack; Hiba A. Awooda; Sana Eltahir Abdalla
    Background: Hemoglobinopathy is a group of inherited disorders characterized by structural variations of the hemoglobin molecule; and sickle cell disease constitutes one of the major genetic blood disorders in Sudan. The aim of this study was to determine the hemoglobin patterns of patients with sickle cell hemoglobinopathies. Methods: This is a hospital based case control study conducted at the Military Hospital, Omdurman. A total of 100 blood samples were collected, 70 cases diagnosed or suspected to have sickle cell disease and 30 was healthy control. Sickling test and hemoglobin (Hb) electrophoresis were performed using Capillary 2 Flex Piercing (SEBIA). Results: Capillary Hb electrophoresis exposed the following variants of sickling hemoglobinopathies among cases group: 37 patients (52.9%) AS pattern, 1 patient (1.4%) AS/C Pattern, 8 patients (11.4%), S/B Thalassemia pattern, 1 patient (1.4%) S/C pattern, 3 patients (4.3%) S/D pattern and 20 patients (28.6%) SS pattern. While Hb electrophoresis obtained from normal healthy controls' group revealed normal expected values, the means of HbA (α2β2) was 95% with small amounts (<3.5%) of Hb A2 (α2δ2) and Hb F (α2γ2). The mean level of Hb was lower in patients' group while HbA2 demonstrated no significant change, while HbF and HbS showed different levels according to the type of hemoglobinopathy. Conclusion: Different variants of sickle cell hemoglobinopathies were identified; AS patterns, AS/C patterns, S/B Thalassemia patterns, S/C patterns, S/D patterns and SS patterns were reported. Hemoglobin A2 had no significant difference in patients with sickle cell disease, while Hb F and Hb S showed significant elevation.