Frequencies of Red Blood Cells AIIO—antibodies among Sudanese Multiparous Women

Abstract

Abstract Background: allo-immunization against red blood cells was tested among Sudanese multiparous women. The study was conducted on randomly selected 130 pregnant ladies, majority were attending Soba teaching hospital whereas the remaining were attending Khartoum teaching hospital during the period February-2008 and May-2008. Aim: the aim of this study was to detect the frequency and type of allo-antibodies, thus highlighting the importance of performing antibody screening and identification in our blood banks in Sudan. Samples and methods: samples were collected from pregnant ladies. Each sample was ABO Rh (D) grouped and screened for allo- antibodies, then samples that gave positive antibody screening were tested for antibody identification using gel agglutination method. Results: red cell allo-antibodies were found in 14 cases (10.8%). The identified antibodies were anti Le“ 4 (28.6%), anti C" 2 (14.3%), anti E 2 (14.3%), anti S 1 (7.1%) and 5 (35.7%) were difficult to interpret whether they are anti Kell or anti Lub. Also the results revealed that, no significant relation was found between age, ethnic group, and presence of allo-antibodies. Also insignificant relation was found

between history of red cell transfusion and allo-immunization; this may be for the small number of tested ladies. ‘A significant relation was observed between history of abortion, number of pregnancies and presence of allo-antibodies. Conclusion: antibody screening should be performed for all pregnant ladies. '