Association of Renal Function Test with Outcome of Hospital Admitted Corona-virus Disease-19 patients (COVID-19) at Khartoum State

Abstract

Abstract Background: The COVID-19 is global pandemic disease and reached Sudan in 13 March 2020, this virus life threating and have large mortality rate. Recent data have suggested the presence of a reciprocal relationship between COVID-19 and kidney function. To date, most studies have focused on the effect of COVID-19 on kidney function, whereas data regarding kidney function on the COVID-19 prognosis is scarce. Objective: To find the association of kidney ftmction test with outcome of hospital admittedCOVID-19 patients. Materials and Methods: The study was retrospective-prospective cohort study conducted at Khartomn state during period from January to April 2021. A total of 80 admitted patients (25-82 years) in Universal Hospital were included. The demographic, clinical, and laboratory (urea, creatinine and GFR) Data were retrieved from individual clinical record. Patients were grouped into recovered and died groups according to their outcome. Statistical analysis was done using SPSS version 25. Results: Amongst 80 confirmed COVID-l9patients, 35 (43.8%) were recovered and discharged whereas the remaining 45 (56.2%) were Died. The result showed that significantincrease in mean of plasma urea (p value 0.045 and plasma creatinine (p value 0.00) respectively, also significant decrease in mean of GFR (p value 0.00). in ROC curve analysis, the AUC of GFR (0.85 p value 0.00) showed higher combined sensitivity (91%) and specificity (67%) values with cut=off 73 ml/min * 1.73 m’. Conclusion: Renal Function Testes (urea, creatinine and GFR) were strongly associated with outcome (death) of COVID-19. Low GF R on admission could be considered as independent risk factor for COVID_19 mortality.