Anticancer activity of 5-Substituted 2-[2‘-(N,N- Dimethylamino)] ethyl-9- aza- anthrapyrazoles against LoVo epithelial tumor cell line-a QSAR mechanistic analysis

Abstract

Abstract Anticancer activity of sixteen known 2-[2‘-(N,N- Dimethylamino)]ethyl-9-Aza-Anthrapyrazoles against LoVo Tumor Cell Line were picked up from literature. Some of their physicochemical parameters which include molar refiactivity, molar volume, and polarizability were calculated using ACD/lab freeware. The biological activity data was obtained as log IC50. Pairing of parameters with biological activities gave three main datasets. Regression analysis done for these main sets to give very poor correlations as indicated by R2. In order to extract good correlations from our sets, we divided of them according to the similarity of outermost moiety in the C5 side chain. This yields four sub sets (each of which composed of four compounds). We had traced activity pattern for these sub sets using R2 as an index. All subsets followed consistent activity profiles explainable statistically and/or chemically.