Assessment of Cardiac Biomarkers among newly Diagnosed cardiovascular disease Patients in Khartoum State

Abstract

Background: Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels, There are many diagnostic pathway to increase awareness of CVD among patients. This study was conducted to assess the activity of cardiac enzymes especially (T.CK, AST) &concentration of cTnI in all type of newly diagnostic CVD patients as cross sectional study to determine the impact of the disease on the heart.

Methods: This study is a cross- sectional study conducted in sudan heart center and AL- Shaab Teaching Hospital at Khartoum state in Sudan during period of November 2016 to January 2017. Sixty newly CVD patients were selected to participate in this study, 44 of them above 50 years and 16 below 50 years cardiac enzymes measured by Mindary BA88 for (T.CK, AST), & cTnI measured by immunoenzymometric assay using TOSOH ALA system. Results in this study there was 28 patients having CVD plus HT, and 27 patients having CVD plus DM and 15 patients having CVD plus (DM, HT) and 17 patients having CVD plus obesity. The mean level of T.CK, AST & cTnI in comparison with Reference value revealed a significance difference. The mean level of (CK, AST) and cTnI when compared between the two age group (<50, >50 years) observed a significant different. The mean level of T.CK, AST & cTnI in CVD smoker was found significantly increased when compared with non smokers CVD patients. The mean level of T.CK, AST & cTnI in CVD diabetic patient was increased when compared with non diabetic CVD patients. The mean level of T.CK, AST & cTnI in CVD hypertensive patient was when compared with non hypertensive CVD patients. As will as in Comparison between CVD alon patients as group and CVD with other risk (DM, HT) the mean levels also observed increased significantly in the second group. Conclusions The cardiac enzymes (.TCK, AST) and cTnI is increased significantly among CVD patients and highly increased in patients with risk (DM, HT, smoker and obesity).