Association of some non genetic factors with eNOS gene polymorphism in diabetic septic foot Sudanese patients

Abstract

Diabetic septic foot [DSF] is a common disabling problem and frequently leads to amputation of the leg. It is also considered as one of the leading cause of morbidity and mortality especially in developing countries like Sudan. The number of cases and the problems associated with DSF infections have dramatically increased in recent years. In this study some non genetic factors and eNOS gene polymorphism of DSF Sudanese patients has been investigated across different origin groups. A group of 74 DSF- diabetic (case) and 80 non-DSF diabetic (control) were collected included the demographic data indicated that most affected DSF patients are males (83.80% ) ranged between from 45-60 years old that originate from westem and northem Sudan, The socio- economic status is not different between case and control groups, however, a significant association between smoking and incidence of DSF was observed (p=0.0l), and most DSF patients(39.60%) fall in class fom according to Wagner’s classification. The frequencies of eNOS gene polymorphism (Glu298Asp) showed no significant differences (p.value= 0.8) in the DSF and non DSF groups (p.value= 0.9). Based on our results, we can conclude that there are some non genetic factors that may affect the developing of DSF and eNOS gene polymorphism may not contribute to it although it's statistically not significant.