Assessment of Testosterone and Cholesterol level in female with Poly Cystic Ovarian syndrome

Abstract

Abstract

Background: Polycystic ovary syndrome is a heterogeneous endocrine disorder which affects 5–15% of the general population, depending on the ethnicity and the applied classification system, Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age It is characterized by polycystic ovaries, oligo-amenorrhea, and hyperandroginism. Objective: The aim of this study is to assess testosterone and Cholesterol in patients with polycystic ovary syndrome (PCO).Methods: This case control study was conducted at Alsir Abu Hassan center for fertility in Khartoum State, the study carried out on a total sample of 100 females including 50 females with polycystic ovary syndrome patients as case and 50 healthy females as control group. Serum testosterone levels was estimated using Enzyme linked immune sorbent assay technique and serum Cholesterol level was estimated using Cobas( C111) . Data analyzed using SPSS software program . Results: In this study, serum mean levels of cholesterol and testosteronewere significantlyincreased in polycystic ovary patients when comparedwith reference group(290.2 ± 38.8 vs. 178.7 ± 191.6, p= 0.000), (2.23± 1.5vs. 0.38± 0.35 p=0.000) respectively.According to menstrual regularity, there were no significant difference in the level of cholesterol and testosterone in patients with regular MCcompared to those with irregular MC (287 ± 32 vs. 291 ± 41, p= 0.71), (2.6 ± 1.6 vs. 2.1 ± 1.5, p= 0.34) respectively. According to family history, there were no significant difference in the level of cholesterol and testosterone in patients who have family historycompared to those who have not (288 ± 37 vs. 291 ± 40, p= 0.81), (2.2 ± 1.5 vs. 2.2 ± 1.6, p= 0.96) respectively. According to number of cysts, there were no significant difference in the level of cholesterol and testosteronein patients who have more than 10 cysts compared to those who have less than 10 cysts (280 ± 48 vs. 298 ± 25, p= 0.11), (1.9 ± 1.6 vs.2.5 ± 1.5, p= 0.27) respectively. According to site of cyst, there were no significant difference in the level of cholesterol and testosterone in patients who have cysts in right ovary, left ovary or both (292 ±43 vs. 283±34 vs. 292 ±40, p= 0.77), (2.2±1.5 vs. 2.5 ± 1.6 vs. 2±1.5, p= 0.56) respectively. Serummean levels of cholesterol and testosterone were insignificantly correlated with age and duration (r= -0.129 and 0.246, p= 0.372 and 0.086), (r=0.013 and 0.166 p= 0.931 and 0.250) respectively. Conclusion: From the results and finding of this study, it is concluded that The serum levels of testosterone and cholesterol are significantly elevate in PCOs female patients.

المستخلص :

الخلفية: متلازمة المبيض المتعدد التكيسات عبارة عن اضطراب غير متجانس في الغدد الصماء ينتشر من 5 إلى15٪ من عامة السكان، اعتمادً اعلى العرق ونظام التصنيف المطبق، متلازمة تكيس المبايض هي أكثر اضطرابات الغدد الصماء شيوعً ابين النساء في سن الإنجاب. تتميز تكيس المبايض، قلة الطمث، وفرط الأندروجينية. وبالتالي، فإن الهدف من هذه الدراسة هوتقييم هرمون التسيتيرون و الكلسترول في المرضى الذين يعانون من متلازمة المبيض المتعدد التكيسات . الطريقة: أجريت هذه الدراسة المقطعية في مركزالسرأبوالحسن للخصوبة في ولاية الخرطوم، وقد أجريت الدراسة على عينة إجمالية من 100 إناث من بينهم 50 إناث مصابات بمرض متلازمة تكيس المبايض كحالة و 50 إناث أصحاء كمجموعة مراقبة. تم تقدير مستويات هرمون تستوستيرون في الدم باستخدام تقنية مقايسة المادة الماصة المرتبطة بالإنزيم وكذلك تم تقدير مستوى الكلسترول بجهازCobas C111)). تم تحليل البيانات باستخدام التحليل الاحصائي SPSS . النتائج: أظهرت هذه الدراسة أن مستويات هرمون تستوستيرون قد زادت بشكل ملحوظ مع(قيمة.(P 0.000