Serum Electrolyte and Bone Mineral Status in Sudanese Patients with Thyroid Dysfunction

Abstract

ABSTRACT Objectives: This study was conducted to investigate the impact of thyroid dysfunction and treatment on serum electrolytes and bone mineral. Design: A case control study period from December 2012 to February 2013. Outpatient attending Radiation and Isotopic Center of Khartoum (RICK). Material and Method: 150 Sudanese female were enrolled in the study , fifty hypothyroidism and fifty hyperthyroidsim patients were taken as cases. In addition to fifty healthy volunteers with normal thyroid hormone profile were taken as controls, matching age and sex . The serum magnesium was measured spectrophotomerically,and the kits were supplied from spin react.Serum calcium and phosphorous were estimated by autoanalyzer (mindary-BS200) kits provided from spinreact .Sodium and potassium were estimated by ion selective electrode . and kits were provided from the cormay and the collected Data was analyzed by computerized SPSS program. Result: There is slight decrease in serum sodium and magnesium (133.53 ± 2.65 versus 137.93 ± 3.57, 1.97 ± .32, versus 1.99 ±.37 mg/dl respectively) (p ≥ 0.05) , and significant decrease in serum calcium (8.98±.83 mg/dl versus 9.02 ± .29 mg/dl respectively) ( p ≤ 0.05) ,with significant increase in serum potassium and phosphate(4.99±..65 mmol/l versus 3.99 ±.55 mmol/l and 4.89 ± 0.13, versus 4.03 ± 0.09) ( p ≤ 0.05) level in hypothyroidism group when compared with control group. The study recorded slight increase in serum sodium(141.87 ± 2.65 versus 137.93 ± 9.05 respectively) (p ≥ 0.05) , serum calcium (9.17±..62 mg/dl versus 9.02 ± .29 mg/dl) ( p ≥ 0.05),and phosphate(4.07 ± 0.14, versus 4.03 ± 0.09) ( p ≥ 0.05) , with significant increase in serum magnesium (2.22 ± .32, versus 1.99 ±.37 respectively) ( p ≥ 0.05) , and slight decrease in serum potassium (3.5 ±.36 mmol/l versus 3.99 ±.55 mmol/l ), ( p ≥ 0.05) level in hyperthyroidism group when compared with control group In hypothyroidism patients the study observed significant positive correlation of serum potassium and phosphate with the duration of the disease( p ≤ 0.05), and negatively correlated with the treatment of the disease ( p≤ 0.05), and serum calcium and magnesium level is significantly negatively correlation with the duration of the disease in hypothyroidism patients ( p ≤ 0.05), and positively correlated with the treatment of the disease ( p≤ 0.05).In contrast in hyperthyroidism patient serum sodium, magnesium and phosphate is significantly positively correlated with the duration of the disease( p ≤ 0.05) , and negatively correlated with the treatment of the disease ( p ≤ 0.05). In conclusion: hypothyroidism cause significant increase in serum potassium and phosphours, with significant decrease in serum calcium and magnisum, In contrast hyperthyroidism caused slight increased in serum sodium and calcium, with significant increase in serum magnesium