Assessment of Serum anticardiolipin and antibet2-glycoporotin1 among Sudanese women with recurrent miscarriage in Khartoum state- Sudan

Abstract

Abstract: Introduction: Antiphospholipid antibodies (APA) are a heterogeneous family of approximately twenty auto antibodies directed against phospholipids binding plasma proteins Objective: The aim of the study was to assess of serum anti cardiolipin and serum anti bet2- glycoporotin1 among some Sudanese woman with recurrent miscarriage. Methodology: This study was conducted in Turkey teaching Hospital, Omdurman maternity hospital and Khartoum north teaching hospital in great state of Khartoum from 2014to 2016. The study was performed on 100 patients as the study group and 100 healthy . The age for the control group and the test group were matched. Serum levels of anticardiolipin`(ACL) and serum antibet2-glycoporotin1 ( Aβ2GPI) were measured by enzyme-linked immunosorbent assays. Rustles: There were significant increase in mean of serum anticardilipin antibodies I,IgG ,IgM) ; mean ±SD was (IgA =4.62± 1.9 U/mL) , (12.61± 1.7 U/mL), (6.16± 1.5 U/mL) for patients with recurrent miscarriage compared with control group; mean ±SD (3.52± 3.4 U/mL), (1.92± .48 u/mL), (1.77± .82 u/mL) P value (0 .006), (0.000), (0.000) respectively. The same significant difference (p=0.000). was observed with the serum antibet2-glycoprotein1 in the study group compared to the control group (10.57± 6.5 vs 3.8± 2.5 ) respectively. There was a significant correlation (r.0.239, P<0.017) between the levels of( IgG )ACL and(IgG) anti-beta2 GPI antibodies. ACL frequency was reported in 32% of patients with recurrent miscarriage and in 2% of control group. Conclusions: A significant association was observed between recurrent spontaneous miscarriage and the presence of serum anticardiolipin(IgA,IgG,IgM)and, antibet2-glycoporotin1 (IgG). Also, there was a significant relationship between positive anticardiolipin (Ig G ) and antibet2- glycoporotin1 .