Rheumatoid arthritis and anti-CCP

Abstract

Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disorder characterized by widespread joint inflammation with synovial hyperplasia disease and the most common inflammatory arthritis, affecting from 0.5 to 1% of the general population worldwide (Gabriel, 2001). It is more common in women with female to male ratio of 2 to 4.1 (Gabriel, 1999). The peak incidence between 30 and 50 years (Ceccato et al., 2006