Assessment of Preeclampsia Multiple Biomarkers in Sudan

Abstract

Preeclampsia is a multisystem disorder of pregnancy, which complicates pregnancy. It is a major cause of maternal morbidity and mortality worldwide. Although pre-eclampsia is an important cause of maternal and fetal morbidity and mortality, its aetiology is still under investigation. The aim of the present study was to investigate biochemical markers in preeclampsia predictions. We focused in this study on organs functions and analysis of different analysts, and salts in the preeclamptic females to gather which factors could influence or predict the preeclampsia. Pregnant women were selected, venous blood samples were collected from every patients and controls. Liver and renal function tests were measured for urea, creatinine, uric acid, calcium, magnesium, phosphorus, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct serum bilirubin, sodium and potassium. Urea, creatinine, sodium, potassium, total protein, albumin, total and direct serum bilirubin concentrations were normal in patients and controls. Uric acid, magnesium, aspartate aminotransferase, alanine aminotransferase were found to be markedly increased in patients while calcium and phosphorus were decreased. These results indicate that the elevation of uric acid, magnesium, aspartate aminotransferase enzyme, alanine aminotransferase enzyme and the reduction in serum levels of calcium during pregnancy might be possible contributors in etiology of pre-eclampsia.