Prevalence 0f@Lupus Anticoagulant in Sudanese Ladies with Recurrent Pregnancy Loss.

Abstract

ABSRTACT This study, was done to detect Lupus Anticoagulant in titty patients with three or more recurrent pregnancy losses, from Khartoum Teaching'Hospital, Omdonnan Teaching Hospital, and Khartoum Fertility Centre. The study was carried out in the period from February to July, 2004. Twenty women with nomtal obstetric history, matched to the patients in age and socioeconomic status, were included as controls. The tests used for detecting the Lupus Anticoagulant were the dPT, dAPTT, dRRVT, KCT, and PNP. The study showed that two of the patients (4%) had Lupus Anticoagulant as suggestedby prolonged dAP'I'T, which was not corrected by mixing with normal plasma and was shortened by PNP. No abnormal results were obtained in the controls. The study also showed that although the mean of dAPTT, of the LA positive patients was significantly elevated compared to the LA negative patients (P<0.05), the means of dPT, dRWT, and KCT of LA positive patients compared to LA negative patients showed no statistical significant difference (P>0.005). So our results indicate the dAP'lT is more sensitive in detection of LA than KCT or dRWT.