Evaluation of lipid profile, and trace elements among Kidney Stone patients in Khartoum State.
Date
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
AL-Neelain University
Abstract
Kidney stones, one of the most painfiil of the urologic disorders, are not a product of modem
life and it is one of the most common disorders of the urinary tract, most kidney stones pass
out of the body without any intervention by a physician. Stones that cause lasting symptoms
or other complications may be treated by various techniques.
In this study it is was estimated the lipid profile and some of trace elements in patients and
control groups to correlate between the distribution lipid profile level and trace elements in
the serum with kidney stone formation in Sudanese's patient.
This study was conducted during the period fiom May to September 2014 in Khartoum
State. Sixty blood samples were collected fiom the patients at Urology unit; Alribat
Hospital, Military Hospital and Ibn Sina Hospital along with forty blood samples as a
control. Biochemical analysis of serum samples was can-ied out for the patients and the
control group to estimate the Total Cholesterol (TC), Triacylglycerides (TAG), High-density
lipoproteins (HDL and Low-density lipoproteins (LDL), and some trace elements (Zn, Cu,
Mg and Mn) concentrations.
The results showed that there is relationship between TC, LDL and HDL concentration and
kidney stone disease, while TAG has no effect. It was found that there is a statistical
significant difference in Zn and Mn concentration between the two groups but not in Mg and
Cu concentration. It was noticed that gender has a pronounced effect in disease
development; male were found to have high incidence of kidney stone in comparison with
the female. Moreover the incidence of kidney stone disease was found to be higher in the
patients above 40 years old.
There was a significant relationship between the high consumption of carbohydrates,
margarine and sugar and the incidence of kidney stone formation
It was concluded that there is a link between dyslipidemia and kidney stone risk that is
dependent of other food intake. Specific alterations in the patient lipid profiles may
portend unique aberrations in urine physicochemistry and stone risk, our study
suggested that increase of Zn and decrease of Mn associated with increased risk factor
of kidney stone disease.
Description
A Dissertation Submitted in Partial Fulfillment for the Requirement of the M. Sc.
Degree in Biochemistry and Molecular Biology.
Keywords
lipid profile, Kidney patients