Browsing by Author "Shaaban Khudair"

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    The clinical importance of anti-CCP in early diagnosis of Sudanese patients with rheumatoid arthritis
    (جامعة النيلين - كلية الدراسات العليا, 2014-12-22) Yousif Osman; Shaaban Khudair; Ahmed Bolad
    Background: Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disorder; it is the most common inflammatory arthritis in the world. The early diagnosis and effective treatment of rheumatoid arthritis (RA) can improve the clinical outcome of the disease. Recently, anti-Cyclic-Citrullinated protein antibodies (Anti-CCP) are found to be more specific to RA arthritis although in the early stages when the arthritis is undifferentiated. The objective of this study was to determine the clinical importance and the prevalence of anti-CCP in early diagnosis of Sudanese patients with RA. Methodology This work was a cross-sectional study conducted at Al Ribat teaching hospital (from June 2012 to ? 2014). The study sample included 56 Sudanese patients, known patients of RA who fulfilled the ACR criteria. Demographic and clinical data were collected by questionnaires. All patients and controls sera were investigated for anti-CPP by enzyme linked immunosorbent assay (ELISA). Results The mean age of RA patients in this study was 46.0 (±11.7) years. The control group consisted of 56 Sudanese apparently healthy subjects, 27 (48%) of them were female with mean age of 37 ±17.2years. The anti-CCP antibodies were detected in 60.7% of cases, and in two (3.6%) of the control group. The sensitivity of anti-CCP was 60.7% and specificity of 96.4%. Anti-CCP test has a maximum proportionate reduction in uncertainty (PRU) of 94% for a positive result and 59% for a negative result. Conclusions Anti-CCP antibody has a higher diagnostic specificity and positive predictive value than rheumatoid factor; however its sensitivity was low.
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    Comparison of Rheumatoid Factor and anti-Cyclic-Citrullinated protein antibodies for the Diagnosis of rheumatic arthritis in Khartoum, Sudan
    (جامعة النيلين, 2008) Shaaban Khudair; Mohammed Abbas; Ahmed Bolad; Mowahib Al Edressy
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    Comparison of Rheumatoid Factor and anti-Cyclic-Citrullinated protein antibodies for the Diagnosis of rheumatic arthritis in Khartoum, Sudan
    (جامعة النيلين - كلية الدراسات العليا, 2014-12-22) Shaaban Khudair; Mowahib Al Edressy; Mohammed Abbas; Ahmed Bolad
    Background: The objective of the current study was to determine the sensitivity and specificity of anti-Cyclic-Citrullinated protein antibodies (anti-CCP antibodies) as compared to that of Rheumatoid Factor (RF) in diagnosing patients with rheumatoid arthritis (RA) Methodology Fifty six samples were collected from Sudanese patients (46 females, 9 males) with rheumatic diseases who visited the rheumatology clinic ElRibat Hospital, Khartoum, Sudan. Titers of RF and anti-CCP antibodies of each patient were recorded. Sensitivity and specificity of the test were evaluated using ELISA as the gold standard method. Results The sensitivity of (RF) test (41/56) was 73.2% whereas the sensitivity of Anti CCP test (34/56) was 60.7%. The specificity of RF test (44/56) was 78.6%, whereas the specificity of Anti CCP test (54/56) was 96.4%. Conclusions The combination of anti-CCP and RF tests provides nearly 100% and thus could be helpful in the differential diagnosis of RA and other rheumatic diseases
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    Rheumatoid arthritis and anti-CCP
    (جامعة النيلين - كلية الدراسات العليا, 2014-12-22) Yousif Osman; Shaaban Khudair; Ahmed Bolad
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    Rheumatoid arthritis and anti-CCP
    (جامعة النيلين, 2010) Yousif Osman; Shaaban Khudair; Ahmed Bolad
    Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disorder characterized by widespread joint inflammation with synovial hyperplasia disease and the most common inflammatory arthritis, affecting from 0.5 to 1% of the general population worldwide (Gabriel, 2001). It is more common in women with female to male ratio of 2 to 4.1 (Gabriel, 1999). The peak incidence between 30 and 50 years (Ceccato et al., 2006
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    Rheumatoid arthritis and anti-CCP
    (Al Neelain Medical Research Centre, 2011) Ahmed Bolad, Yousif Osman; Shaaban Khudair