Mohamed Esam Aldien Ahmed2023-01-102023-01-102019-04http://hdl.handle.net/123456789/18576A Dissertation submitted in partial fulillment for the requirement of Msc Degree in clinical chemistryAbstract Background: Diabetes Mellitus is a major endocrine and metabolic disease worldwide. The number ofpatients suffering from diabetes mellitus was reported to be over 200 million people worltlwide. Matty trace elements are important for optimum human metabolic function. Type l bdiabetes mellitus ('l'lDM) may lead to deficiencies in trace elements that have substantial iuttetioits in the human organism. Changes in serum magnesium (Mg). copper (Cu), and zinc (Zn) levels are correlated with metabolic control and diabetes complications. Previous research on the potential roles oi" trace elements in diabetes has focused particularly on chromium, /inc and iron. Objective: the aim of this study was to estimate Level ol‘ Trace lilements (Serum Zinc and Copper) among Sudanese Patients with Type I Diabetes Mellitus in Khartoum State. Materials and methods: in this ease control hospital based study conducted in Khartoum state. fit) subjects were involved. 40 patients with Type I Diabetes (27 males 8413 llzmales) with a mean age of 20.3 years and control group was comprised of 40 healthy lll(.ll\‘ltiLlL\l (22 males & I8 females) with a mean age oi" 20.3 years. Serum level ol' zine and copper measured by colorimetric method in fully Automated llioelteinistry Analyzer. Results: this study showed the mean level ol‘ lib/\lc and serum levels ol‘ zine and copper among Sudanese patients with Type l Diabetes and control group. The mean level olillb/\lc in patients with Type l Diabetes and control group respectively were ((>.98t2.2(J. 4.71 4 l.l2), the mean level ol'serum olixine in patients with Type l Diabetes and control group respectively were (0.5-l*().|(). 0.88 i (l.l3) and the mean level ol'serum otieopper in patients with Type l Diabetes and control respectively were (7l.5t l0.l‘), lO3.8- 14.94). Conclusion: This study concluded that the serum levels otizinc and copper among Sudanese patients with Type l Diabetes was signilieant decrease compared to control group (p value 0.00. ().t)t)) and was a significant increase of the Mean levels of llb/\lc in type l l)M Patients eomparctl with that olicontrol group (p value— 0.()()0j.Diabetes MellitusThesis