Rufayda Omar Musa2023-03-162023-03-162014http://hdl.handle.net/123456789/19025A Dissertation Submitted in Partial Fulfillment for the Requirement of the M. Sc. Degree in Biochemistry and Molecular Biology.Kidney stones, one of the most painfiil of the urologic disorders, are not a product of modem life and it is one of the most common disorders of the urinary tract, most kidney stones pass out of the body without any intervention by a physician. Stones that cause lasting symptoms or other complications may be treated by various techniques. In this study it is was estimated the lipid profile and some of trace elements in patients and control groups to correlate between the distribution lipid profile level and trace elements in the serum with kidney stone formation in Sudanese's patient. This study was conducted during the period fiom May to September 2014 in Khartoum State. Sixty blood samples were collected fiom the patients at Urology unit; Alribat Hospital, Military Hospital and Ibn Sina Hospital along with forty blood samples as a control. Biochemical analysis of serum samples was can-ied out for the patients and the control group to estimate the Total Cholesterol (TC), Triacylglycerides (TAG), High-density lipoproteins (HDL and Low-density lipoproteins (LDL), and some trace elements (Zn, Cu, Mg and Mn) concentrations. The results showed that there is relationship between TC, LDL and HDL concentration and kidney stone disease, while TAG has no effect. It was found that there is a statistical significant difference in Zn and Mn concentration between the two groups but not in Mg and Cu concentration. It was noticed that gender has a pronounced effect in disease development; male were found to have high incidence of kidney stone in comparison with the female. Moreover the incidence of kidney stone disease was found to be higher in the patients above 40 years old. There was a significant relationship between the high consumption of carbohydrates, margarine and sugar and the incidence of kidney stone formation It was concluded that there is a link between dyslipidemia and kidney stone risk that is dependent of other food intake. Specific alterations in the patient lipid profiles may portend unique aberrations in urine physicochemistry and stone risk, our study suggested that increase of Zn and decrease of Mn associated with increased risk factor of kidney stone disease.enlipid profileKidney patientsThesis