The Effect of gum Arabic ingestion on the hormones and the metabolic markers in patients with polycystic ovary syndrome

Abstract

Abstract Background Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age. associated with multiple metabolic abnormalities, pathogenesis remain unclear but increased Gonadotrophin releasing hormone pulsitility. altered gut microbiome and oxidation stress play a major role. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, is known for its prebiotic and antioxidant properties. Objective The main objective was to assess the changes in hormonal and metabolic profile in PCOS patients afier gum Arabic ingestion. Method Fifteen PCOS patients aged 20-40 years were recruited. All recruited patients met the inclusion criteria The patients received 30 g/day of GA dissolved in 250 ml water for 8 weeks. Follicular stimulating hormone(FSH), luteinizing hormone(LH), total testosterone(TT) fasting insulin, cholesterol and HBAW were measured before and after GA intake. Ethical approval from the National Medicines and Poisons Board was obtained. Results The study clarified that there is asignificant decrease in theluteinizing hormone level and the FSH/ LH ratio and the cholesterol pre and post intervention (P values 0.001, 0.0l3and 0.007) respectively. Follicular stimulating hormone slightly reduced post intervention with no significant difference (P value 0.414). No change in the testosterone, insulin nor HBAIC levels. Conclusion The study demonstrated that Gum Arabic ingestion for 8 weeks in PCOS patients decreases the luteinizing hormone and LH/FSH ratio and improve the metabolic profile by decreasing the cholesterol level.