Antibody-mediated in vitro growth inhibition of field isolates of Plasmodium falciparum from asymptomatic children in Burkina Faso

Abstract

Antibody-mediated inhibition of Plasmodium falciparum parasites in vitro reflects the

potential parasite-neutralizing activity of the antibodies in vivo. In this study,

immunoglobulins and P. falciparum isolates were collected from children with asymptomatic

malaria in Burkina Faso. We demonstrate a significantly lower in vitro growth inhibitory

activity against the P. falciparum field isolates by autologous host immunoglobulin compared

with that of immunoglobulin from other individuals. To gain further insight to possible ...