المقالات العلمية – كلية الطب
Permanent URI for this collectionhttps://repository.neelain.edu.sd/handle/123456789/4594
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Item Association between H. Pylori and Urticaria or Gastritis(مركز النيلين الطبي, 2015) Ahmed Bolad, Sheema Mohsin Mustafa; Maha Ibrahim, Tarig Abbas; Alsagad AltayebBackground: Studies have established that Helicobacter pylori can cause chronic gastritis. Recent evidence suggests that Helicobacter pylori infections play a great role in the pathogenesis of a variety of skin diseases, the best evidence for such a link is found for two diseases; chronic urticaria and immune thrombocytopenic purpura. Objectives: the current study is aiming at evaluating the relationship between H. pylori among patients with different cutaneous problems mainly chronic urticaria by using immunological methods. On the other hand the study is aiming at verifying the effect of treatment on the prevalence of disease. Materials and Methods: 119 Specimens (blood and stool samples) were obtained. Serum was stored at -20°C until used. Stool was collected in clean container and tested immediately. Specimens were processed by Serum ICT (ACCURATE, diagnostic use, china) and Stool Antigen ICT KITS (CERTEST BIOTEC S.L.) for detection of H. pylori. Significance tests, measures of accuracy and confidence intervals were calculated using the biomedical Stats Direct Statistical Software v2.7.9 (7/9/2012). IBM SPSS Statistics v22 was used in the descriptive data analysis. Results and discussion: H. Pylori infection was detected in about half of the patients who suffered from either urticaria or gastritis. The prevalence of H. Pylori was estimated in the three groups as 48.3% (CI: 35.2% to 61.6%); in the urticaria group, 51.7% (CI: 32.5% to 70.6%); in the gastritis group and 13.3% (CI: 3.8% to 30.7%) in the apparently healthy group (labelled ‘Normal’). Proportions of H. Pylori infection in the urticaria and the gastritis groups were not NMJ June 2015 vol.3 No.16 ISSN 1858-6155 NMJ 2015 statistically significantly different. Both groups, however, had a significantly different proportion of HP infected patients when compared with the apparently healthy (Normal) group. This statistically significant difference was suggestive of an association between H. Pylori and both of urticaria and gastritis.Item Detection of Helicobacter pylori Reactive IgA and IgG Antibodies Using Enzyme Linked Immunsorbent Assay (ELISA)(Sudanese Association of Dermatologists, 2010) Ahmed Bolad, Samah Seif Eldein; Mohamed LutfiBackground: Helicobacter pylori (H. pylori) infection is usually acquiredduring the early years of life and persists for several years. Recent investigations pointed to a potential role of H. pylori infection of the upper gastrointestinal tract as a possible causative agent in chronic urticaria (CU).Objectives: This study is aiming at evaluating the relationship between H. pylori and chronic urticaria in Sudanese patients.Methods and patients: Fifty patients with idiopathic CU, twenty five ofother skin disorder and ten healthy controls were enrolled estimated for serum H.pylori Immunoglobulin G (IgG) and A (IgA) antibodies levels using Enzyme Linked Immunsorbent Assay (ELISA). All the results were analyzed using the Microsoft Office Excel (Microsoft Office Excel for windows; 2003) and SPSS (SPSS for windows 17).Results and discussion: The IgG and IgA levels of control group weresignificantly lower compared with both patients with chronic urticaria (P = 0.001 for IgG) (P = 0.001 for IgA) and patients with other skin disorders (P = 0.011 for IgG) (P = 0.006 for IgA). Receiver Operating Characteristic curve (ROC curve) analysis revealed that the area under ROC curves of IgA is higher compared to IgG (0.80 0Vs 0.890). In conclusion the current study revealed that patients with H. pylori infection have an increased tendency to develop urticaria. H. pylori reactive IgA antibodies correlate best with the infection.