المقالات العلمية – كلية الطب
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Item The clinical importance of anti-CCP in early diagnosis of Sudanese patients with rheumatoid arthritis(2015) Ahmed Kamal BoladBackground: Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disorder; it is the most common inflammatory arthritis in the world. The early diagnosis and effective treatment of rheumatoid arthritis (RA) can improve the clinical outcome of the disease. Recently, anti-Cyclic-Citrullinated protein antibodies (Anti-CCP) are found to be more specific to RA arthritis although in the early stages when the arthritis is undifferentiated. The objective of this study was to determine the clinical importance and the prevalence of anti-CCP in early diagnosis of Sudanese patients with RA. Methodology This work was a cross-sectional study conducted at Al Ribat teaching hospital (from June 2012 to ? 2014). The study sample included 56 Sudanese patients, known patients of RA who fulfilled the ACR criteria. Demographic and clinical data were collected by questionnaires. All patients and controls sera were investigated for anti-CPP by enzyme linked immunosorbent assay (ELISA). Results The mean age of RA patients in this study was 46.0 (±11.7) years. The control group consisted of 56 Sudanese apparently healthy subjects, 27 (48%) of them were female with mean age of 37 ±17.2years. The anti-CCP antibodies were detected in 60.7% of cases, and in two (3.6%) of the control group. The sensitivity of anti-CCP was 60.7% and specificity of 96.4%. Anti-CCP test has a maximum proportionate reduction in uncertainty (PRU) of 94% for a positive result and 59% for a negative result. Conclusions Anti-CCP antibody has a higher diagnostic specificity and positive predictive value than rheumatoid factor; however its sensitivity was low. The clinical importance of anti-CCP in early diagnosis of Sudanese patients with rheumatoid arthritis (PDF Download Available). Available from: https://www.researchgate.net/publication/286931967_The_clinical_importance_of_anti-CCP_in_early_diagnosis_of_Sudanese_patients_with_rheumatoid_arthritis [accessed Sep 26, 2017].Item Reliability of Anti-Cyclic Citrullinated Peptide Antibodies (Anti-CCP) for the Diagnosis of Rheumatoid Arthritis as Compared to that of Rheumatoid Factor test(2013-03) Ahmed Bolad, Ayman Atea; Howeida Mustafa, Mohammed Lutfi; Khalifa KhalafallaBackground: Rheumatoid factor (RF) is commonly used for diagnosis of rheumatoid arthritis (RA). RF positivity is nonspecific for diagnosis of RA because it can be detected in 3-5% of normal individuals. Recent studies indicated that anti-Cyclic-Citrullinated protein (Anti-CCP) antibodies are more specific to diagnose rheumatoid arthritis and have the capacity to diagnose RA in early stages of the disease, or even before the onset of the disease when the arthritis is undifferentiated. Objectives: This study has been conducted to assess the reliability and specificity of anti- CCP in Sudanese as an indicator of RA. Patients and methods: In this study, patients were diagnosed as RA patients according to the American College of Rheumatology (ACR) criteria. To get further insight on the sensitivity and specificity of Anti-CCP test as compared to that of RF test in the diagnosis of RA, analysis of samples obtained was performed using enzyme linked immune sorbent assay (ELISA) and latex agglutination test. All the results were analyzed using Statistical Packages of Social Sciences (SPSS). Results and discussion: Anti-CCP test achieved higher specificity (86.7% Vs 60%) and sensitivity (74.3% Vs 60%) compared with RF. However, despite that the accuracy of anti-CCP to diagnose RA was high (76.5%), the false negative rate reached 21.2%. Although anti-CCP test is more accurate compared with RF; it may sometimes fail to diagnose some patients with rheumatoid arthritis. However, studies on the predictive values and other conditional ratios for anti-CCP antibodies were scarce.