المقالات العلمية – كلية الطب

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    Do Patients with Psychiatric Diseases Tend to Have Positive SLE Reactive autoantibodies and Vitamin B12 deficiency
    (AlNeelain Center for Medical Research, 2013) Ahmed K Bolad, Atif A Elagib; Ezeldine K Alturabi
    Background: the relationship between neuropsychiatric manifestations and systemic lupus erythematosus (SLE) reactive autoantibodies, VitaminB12 and Folate levels are controversial and were not investigated before in Sudanese psychiatric patients. Aim: to determine the association between psychiatric manifestations and several SLE reactive autoantibodies, Vitamin B12 and Folate levels. Material and Methods: the study involved a test group of one hundred psychiatric patients and age/gender matched control group of one hundred apparently healthy subjects. Antinuclear antibodies (ANA), anti-double stranded DNA (anti-dsDNA) antibodies and ANA profile, Vitam. B12 and Folate levels were measured for each studied subject using ELISA method. The association between various SLE reactive antibodies and psychiatric illnesses were assessed using Mid-P extract test. P < 0.05 was considered significant. The association between Vitam.B12 or folate deficiencies and psychiatric illness were assessed using fisher extract test. P<0.05 was consider significant. Results: all subjects in the control group were ANA and dsDNA negative, however, only one (1%) was positive for anti-histone antibody (ANA profile). Regarding patients with psychiatric diseases, 6% were ANA positive, 2% were dsDNA and 6% ANA profile positive. In contrast to dsDNA, there were significant associations between psychiatric diseases and ANA and/or ANA مجلة النيلين الطبية – العدد العاشر 2013 June NMJ profile antibodies (P = 0.007 for ANA, P = 0.0125 for dsDNA and P = 0.033 for ANA profile). Significant association was found in the levels of Vitam.B12 deficiency and psychiatric diseases. No significance was found in the folate level. Conclusion: Sudanese patients with psychiatric diseases tend to have positive SLE reactive autoantibodies especially for ANA and ANA profile antibodies and Vit B12 deficiency.