Browsing by Author "Omima Mohammed Adam"

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    Risk of Thrombosis in Upper GIT Bleeding Patients
    (Al Neelain University-Faculty of Medical Laboratory Sciences, 2016-02) Omima Mohammed Adam; Hiba BadrEldin Khalil
    Introduction: Upper Gastro-Intestinal (GIT) bleeding is a serious emergency that results in high morbidity and mortality, and therefore requires admission to the hospital for emergency and urgent diagnosis and management. Objective: This study aimed to assess the thrombotic marker D-dimer (D.D) level in patients with upper GIT bleeding due to different etiology. Materials and Methods: 2.5 ml of citrated venous blood were collected from 46 Sudanese patients diagnosed by endoscopy as having upper GIT bleeding; 32 of them were males and 14 were females with age ranged between 18-75 years. The D-dimer level was measured by i-CHROMA quantitative immunoassay. Results: D-dimer (D.D) level was increased according to the severity of bleeding; In mild cases, the mean of D.D was 311.8 ng/ml, while in severe cases, the mean was 2332ng/ml. Based on the etiology of upper GIT bleeding, it seemed highest (2652ng/dl) in patients who intake ibuprofen or naproxen for long time, while patients with bile reflux, it was a little lower (2639ng/dl). On the other hand, patients who had upper GIT bleeding due to stress, their D.D level was (1732ng/dl), and patients with bleeding due to eaten corrosive substance was (1404ng/dl). Finally, patients had bleeding due to H. pylori positive, their D.D level was (872ng/dl). Conclusions: Although most of the patients were suffered from upper GIT bleeding (mild or sever) due to different reasons, but they showed D-dimer level higher than the reference value. D-dimer is a simple test results to exclude thrombosis and it should be performed for patients with upper GIT bleeding for treatment management and follow up.