Browsing by Author "Misaa Omer Mohamed"

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    Immunohistochemical Expression of Vascular Endothelial Growth Factor in Ovarian Cancer among Sudanese Females A
    (AL-Neelain University, 2013) Misaa Omer Mohamed
    Abstract This was descriptive retrospective cross sectional study it was conducted in Khartoum state in Omdurman military hospital and at the center of Isotope and Nuclear medicine Khartoum (RICK). During the period from May –junuary2017.This study aimed to detect vascular endothelial growth factor expression in serous and mucinous ovarian cancer among Sudanese patients by using immunohistochemical method and The study was also aimed to correlate with patient age. Thirty eight samples were selected .Using formalin fixed paraffin embedded block of ovarian tissue; expression of VEGF was assessed immunohistochemically. The ages of the involved patients were ranged between 26 to 70 years old; The majority of the patients more than 47year were between age group (47 to 58) years old . Histopathological diagnosis of the studies samples revealed that ten samples (71.4%) out of 14 ovarian samples with mucinous adenocarcinoma were exhibit positive expression for VEGF, the reminders 4samples (28.6%) were negative for VEGF. Out of 24 samples with ovarian serous adenocarcinoma, 19 of them (79.2%) were exhibit positive expression of VEGF; the remainders samples were negative for VEGF. There was no positive expression in age groups (26-36) (5.3%) , 9 ( 23.7%) were positive and 2 (5.2%) were negative in age group (37-47) (28.9) , in age group (48-58) (42.1%) , 12 (31.5%) were positive and 4 (10.5%) were negative in age group (59-70) (23.7%) 8 (21%) were positive and 1 (2.6%) were negative and the result statistically insignificant p-value (0.044). Our findings showed no statistical significant (P- value (0.855) correlation between the serous and mucinous cancer of ovary and VEGF. There was statistical association between age and expression of VEGF and this may be due to small number of sample included in our study. الخلاصه كانت هذه دراسة وصفيه بأثر رجعي وأجريت هذه الدراسة في ولَية الخرطوم في مستشفى أم درمان العسكري ومركز الخرطوم للعلاج بالَشعه والطب النووي . خلال الفتره من مايو الي يناير 7102 . هدفت هذه الدراسه للكشف عن إفراز عوامل نمو خلايا الأوعيه الدمويه والإندوثيليه قي سرطانات المبيض المخاطيه والمائيه بين المصابات السودانيات بإستخدام تقنيات الأنسجه المناعيه وهدفت هذه الدراسه أيضا للمقارنه ما بين الَفراز والعمر. تم اختيار 83 عينه من سرطانات وإفراز عوامل نمو خلايا الأوعيه الدمويه والإندوثيليه قيمت باستخدام تقنيات الأنسجة المناعية 21 سنه واغلب المرضي أعمارهم اكبر من 72 بين الفئه - اعمار المرضي تتراوح بين 72 82 ( عينه من سرطانات المبيض %( 83 والتشخيص النسيجي للعينات 07 - العمريه 73 20.7 ( منها هي عينه إيجابيه لإفراز عوامل نمو خلايا %( المخاطية وبعد الصبغ وجد ان 01 73.2 (سلبيه , %( الأوعيه الدمويه والإندوثليه والباقي منها 7 19 %) 2..7 ( عينه من 77 28% ( عينه من سرطانات المبيض المائية إيجابيه ( , والباقي منها سلبيه . - لَتوجد عينه ايجابيه لإفراز عوامل نمو خلايا الأوعيه الدمويه والإندوثليه في القئه العمريه 72 - 72 ( و في القئه العمريه) 73 - 8.7 ( سلبيه في القئه العمريه) 82 ( 82 و. ) 78.2 (ايجابيه و 7 7.2 ( سلبيه في القئه ( 71.8 (ايجابيه و 0 ( 01.8 (سلبيه و 3 ( 80.8 ( ايجابيه و 7 ( 07 ) )83 العمريه في هذه الدراسة وجد انه لَ توجد فروقات ذات دلَله ما بين عوامل نمو خلايا الأوعيه الدمويه والإندوثليه ق سرطانات المبيض المخاطيه والمائيه وايضا لَتوجد فروقات ذات دلَله ما بين عوامل نمو خلايا الأوعيه الدمويه والإندوثليه وهذا لعدم وجود عدد عينات مناسب.