Browsing by Author "Hiba BadrEldin Khalil"

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D-dimer a predictive test for thrombosis risk in Chronic Myeloid Leukemia patients
(2018) Naglaa Awad Elseed Mohamed; Hiba BadrEldin Khalil
Background; A systemic activation of blood coagulation and pro-coagulant change in the hemostatic system has frequently been observed in cancer patients, even in the absence of venous thromboembolism. Chronic myeloid leukemia (CML), also known as “chronic myelogenous leukemia,” is a type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood. D-dimer is a biomarker that globally indicates the activation of homeostasis and fibrinolysis. Studies conducted that patients of myeloid leukemia, some were during treatment, there was an increase of fibrinolysis activity as a significant increase of D-dimer was observed after 24h of treatment, suggested the influence of the cure on coagulation and fibrinolysis systems. Materials and Methods; The study recruited 42 patients diagnosed by Chronic Myeloid Leukemia. Venous blood was collected for estimation of total white blood cells count, blast count and D-dimer assay. Results and Conclusions; CML patients were at risk for thrombosis. Positivity of D-dimer was not related to leukocytosis nor treatment. Elevation of the D-dimer was associated with the blast count.
Risk of Thrombosis in Upper GIT Bleeding Patients
(Al Neelain University-Faculty of Medical Laboratory Sciences, 2016-02) Omima Mohammed Adam; Hiba BadrEldin Khalil
Introduction: Upper Gastro-Intestinal (GIT) bleeding is a serious emergency that results in high morbidity and mortality, and therefore requires admission to the hospital for emergency and urgent diagnosis and management. Objective: This study aimed to assess the thrombotic marker D-dimer (D.D) level in patients with upper GIT bleeding due to different etiology. Materials and Methods: 2.5 ml of citrated venous blood were collected from 46 Sudanese patients diagnosed by endoscopy as having upper GIT bleeding; 32 of them were males and 14 were females with age ranged between 18-75 years. The D-dimer level was measured by i-CHROMA quantitative immunoassay. Results: D-dimer (D.D) level was increased according to the severity of bleeding; In mild cases, the mean of D.D was 311.8 ng/ml, while in severe cases, the mean was 2332ng/ml. Based on the etiology of upper GIT bleeding, it seemed highest (2652ng/dl) in patients who intake ibuprofen or naproxen for long time, while patients with bile reflux, it was a little lower (2639ng/dl). On the other hand, patients who had upper GIT bleeding due to stress, their D.D level was (1732ng/dl), and patients with bleeding due to eaten corrosive substance was (1404ng/dl). Finally, patients had bleeding due to H. pylori positive, their D.D level was (872ng/dl). Conclusions: Although most of the patients were suffered from upper GIT bleeding (mild or sever) due to different reasons, but they showed D-dimer level higher than the reference value. D-dimer is a simple test results to exclude thrombosis and it should be performed for patients with upper GIT bleeding for treatment management and follow up.