Browsing by Author "Ahmed Bolad, Abdelrahman Manofaly"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Diagnosis of autoimmune diabetes in adults using Immunological methods in Khartoum-Sudan
    (Basic Research Journal of Medicine and Clinical Sciences, 2015-05-13) Ahmed Bolad, Abdelrahman Manofaly; Maha Ibrahim GadAlla, Safaa A Medani; Husham M Abdelrahim
    Adult's onset diabetes represent a heterogeneous mixture of type 1 and type 2 DM, often difficult to differentiate between. Such patients may actually have latent autoimmune diabetes in adults (LADA) which is an autoimmune form of DM, where beta-cell destruction is less aggressive, leading to a slower development of insulin dependency. Detection of glutamic acid decarboxylase auto antibodies (GADA) using Enzyme Linked Immunosorbant Assay (ELISA) method is a useful immunological method for diagnosis of (LADA). The aim of this study was to diagnose (LADA) patients using ELISA method to detect GADA and to identify patients who fit into the criteria of (LADA) from diabetic patients wrongly diagnosed as having type 2 DM. The study was cross sectional, conducted in El-Ribat University Hospital, in Khartoum, Sudan during the period April to May 2012. Fifty 40-60 years old patients diagnosed as type 2 DM were included; all had elevated fasting blood glucose (FBG) not responding to oral hypoglycemic agents. Results showed that 6% of these patients were GADA +ve thus proving that some patients with Type 2 DM not responding to oral hypoglycemic agents were in fact suffering from latent type1 DM; using immunological methods have a beneficial role in diagnosing such patients.