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Title: Evaluation the Serum Levels of Gonadotropin Hormones and Total Testosterone in Sudanese Male Patients with Diabetes Mellitus Type2
Authors: Sharaf O. Mohammed Alamein
Suhair A.Ahmed
AbdElkarim A. Abdrabo1
Keywords: Body Mass Index (BMI)
Type 2 diabetes mellitus.
Issue Date: Feb-2016
Publisher: Al Neelain University-Faculty of Medical Laboratory Sciences
Series/Report no.: 5;
Abstract: Background: Type 2 diabetes mellitus has been shown to be associated with certain endocrine disorders in men. We therefore investigated the levels of male sex hormones in serum of patients with type 2 diabetes mellitus (DM2) and non-diabetic controls (NDMC) with a view to establish the effect of diabetes mellitus on their endocrine system. Methods: Case control study was conducted at primary heath care center (Alfaraby) in Khartoum state during the period from January to February 2016.Ninety subjects were enrolled in this study , 60 diabetic male subjects classified according to their BMI as 30 patients with BMI less than 25Kg/M2 and 30 patients with BMI more than 25Kg/M2 .( BMI: normal weight (18.5-24.9 Kg/M2), and Obesity (30-39.9 Kg/M2). The other 30 are healthy subjects as control. Fasting plasma glucose (FPG), male sex hormones (follicle stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone) were estimated. Results: The mean value of FPG, FSH and LH were significantly higher in diabetic subjects when compared with the control group (NDMC), there was significant difference in the levels of LH, FSH and BMI. The level oftotal testosterone was significantly lower in diabetics normal weightthan in NDMC (P. value =0.001). The level of total testosterone was significantly lower in diabetics obese than in NDMC (P=0.000). There was no significant correlation between duration of diabetes and male sex hormones (FSH, LH, and total Testosterone).Results also showed that Total testesterone, LH, are dependent of age (P. value = 0.01, P. value=0 .038) respectively. Conclusion: The data from this study showed reduction in serum T. testesterone and increase in serum FSH and LH of diabetic patients compared to healthy individuals.
Appears in Collections:مجلة المختبرات الطبية - 2016 - 2- 2

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