Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12071
Title: Genetic polymorphisms of catalase and superoxide dismutase in Sudanese patients with vitiligo. A case – control study.
Authors: Khalid H.Bakheit
Keywords: Catalase
Genotype,
Single nucleotide polymorphism (SNP),
Issue Date: Feb-2017
Publisher: جامعة النيلين - مركز النيلين الطبي
Series/Report no.: No. 19;vol.5 :pag6
Abstract: Abstract Background:Vitiligo is the most common pigmentary skin disorder. It is a multifactorial polygenic diseaseof unknown aetiology, with epidermal melanocytes destruction.The role of the reactive oxygen species and antioxidant enzymes in its pathogenesis was not fully elucidated. In addition, the disease was not extensively studied at the genes level. Objective:We sought to to investigate the genotype variations in the CAT-21A/T SNP in the catalase (CAT) gene and in the SOD1-251A/G SNP in the superoxide dismutase1 (SOD1) gene, betweenvitiligo patients and an age – and sex – matched control group. Methods:DNA was extracted from the whole blood of 54 Sudanese vitiliginous patients and 55 matched control individuals by the spin column procedure.The CAT and SOD1 genes were amplified by the polymerase chain reaction (PCR); and the SNPs were genotyped by the restriction fragment length polymorphism (RFLP) technique using HinfI and MspI restriction enzymes. Results:No significant difference in the alleles’frequencies of the CAT-21A/T and SOD1-251A/G SNPs had been detected between the vitiligo patients and the control group. Moreover, no allele or genotype polymorphism in these two SNPs can be regarded as a risk or a protecting factor for vitiligo. Conclusion:The CAT-21A/T and SOD1-251A/G SNPs have no association with the pathogenesis of vitiligo.
URI: http://hdl.handle.net/123456789/12071
ISSN: ISSN 1858-6155
Appears in Collections:Al Neelain Medical Journal - VOL - 19

Files in This Item:
File Description SizeFormat 
1_19_2.pdf647.15 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.